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The server room is dead. Or dying, anyway.
Medical practices that once maintained expensive on-premise hardware are migrating to cloud-based EHR systems at an accelerating pace.
This shift is powered by cloud computing, which enables healthcare organizations to move away from local servers and embrace more flexible, scalable solutions.
For practices without dedicated IT staff, offloading security patches, HIPAA compliance headaches, and uptime monitoring to specialists removes operational burdens that distract from patient care.
The advantages of cloud-based EHR include cost savings, greater flexibility, and improved access to patient data from anywhere. Why manage servers when you could manage health?
But not all cloud platforms deliver equally.
Some excel at deep customization for specific specialties. Others prioritize out-of-the-box simplicity for practices that just want something that works. A few have genuinely nailed billing integration while their competitors struggle with basic claim scrubbing.
Finding the right fit requires understanding what each platform actually does well for your practice, especially in the context of electronic health record (EHR) systems and their integration with cloud computing.
We examined nine cloud-based EHR systems built for ambulatory practices across different specialties and practice sizes.
Each approaches the market differently; some chase innovation aggressively while others emphasize stability and proven workflows. Here’s what stood out about each platform.
Cloud-based EHR software leverages scalable resources such as processing power and storage, allowing practices to efficiently meet growing demands without investing in additional hardware.
Over the past month, we looked at 9 cloud-based EHR systems that were specifically built for medical practices.
While many share standard features, each has its own strengths worth considering.
Table of Contents
1. What to Look for in Cloud-Based EHR Systems
2. Best Cloud-based EHR Software
3. Completing the Technology Stack
4.How to Decide Which Platform to Pick
What to Look for in Cloud-Based EHR Systems
Cloud-based EHR systems have transformed the way healthcare organizations manage patient data, clinical documentation, and daily operations.
By leveraging cloud technology, these platforms deliver a comprehensive solution that supports efficient, secure, and scalable healthcare delivery.
Here are the key features to look for in the best cloud-based EHR software:
Intuitive User Interface
A user-friendly, intuitive interface is essential for healthcare providers to quickly access patient charts, manage clinical data, and navigate complex workflows.
The best cloud-based EHR systems are designed to minimize clicks and streamline documentation, allowing providers to focus more on patient care and less on software training.
Patient Portal
Good cloud-based EHR platforms include robust patient portal capabilities, empowering patients to access their electronic health records, schedule appointments, check in online, and communicate securely with their providers.
This enhances patient engagement and improves overall satisfaction by making healthcare data more accessible.
Revenue Cycle Management
Integrated revenue cycle management tools help practices manage billing, claims, and payments efficiently.
By automating key processes and reducing manual entry, cloud-based EHR systems support financial health and ensure that providers are reimbursed accurately and promptly.
Clinical Documentation
Comprehensive clinical documentation features enable providers to create, edit, and manage patient charts and encounter notes with ease.
Advanced cloud-based solutions often include ambient listening or AI-powered tools to streamline documentation further, improving accuracy and saving valuable time.
Mobile EHR
With mobile EHR capabilities, providers can securely access patient data, review lab orders, and manage clinical workflows from any location.
This flexibility is increasingly important for practices with multiple locations or providers who need to stay connected on the go, ultimately enhancing patient outcomes.
Practice Management Platform
A fully integrated practice management platform brings together scheduling, medical billing, and patient engagement tools in one place. This centralization simplifies daily operations, reduces administrative burdens, and helps practices deliver a seamless patient experience.
Scalability
Cloud-based EHR systems are designed to grow with your organization. Whether you’re a solo provider or a multi-location healthcare organization, these platforms offer the scalability to add users, expand services, and adapt to changing needs without costly infrastructure upgrades.
Interoperability
The ability to share patient data securely and efficiently with other healthcare organizations is a hallmark of leading cloud-based EHR systems.
Interoperability features ensure that clinical data flows smoothly between providers, supporting coordinated care and better health outcomes.
Security and Confidentiality
Protecting patient data is non-negotiable. Cloud-based EHR platforms prioritize security and confidentiality, employing advanced encryption, access controls, and compliance with regulatory standards like HIPAA to safeguard sensitive healthcare data.
Cost-Effectiveness
By eliminating the need for on-premise servers and reducing IT maintenance costs, cloud-based EHR systems offer a cost-effective solution for practices of all sizes.
Predictable monthly pricing and automatic updates help organizations manage budgets while maintaining access to the latest features and security enhancements.
Best Cloud-based EHR Software
With that out of the way, let’s dive into top cloud EHR systems and what sets them apart.
1. PrognoCIS
Bizmatics built PrognoCIS back in 2001, and the platform has accumulated more than two decades of refinement.
It runs on true cloud infrastructure. There’s no local installation required, and it’s accessible from any browser or mobile device. The company headquarters sits in Silicon Valley, though its customer base spans ambulatory practices nationwide.
That said, the template library deserves attention.
PrognoCIS ships with specialty-specific templates covering internal medicine, pain management, orthopedics, OB/GYN, rheumatology, and more.
Each can be modified down to individual provider preferences without breaking compliance requirements. Pain management workflows differ substantially from pediatric ones, and the system accommodates that variation without requiring practices to build documentation structures from scratch.
Recent additions include AI-powered features under the PrognoAI banner, automated coding suggestions, documentation help, and predictive analytics tools.
The platform integrates practice management directly into the EHR. All these innovations have already led to actual cost savings for early adopters. Athens Neurology documented over $82,000 in annual savings through improved practice efficiency.
2. InSync by Qualifacts
InSync started life focused squarely on behavioral health but has since expanded into broader ambulatory care markets.
Qualifacts acquired the platform and positioned it at small-to-midsize organizations that need room to grow without switching systems every few years.
What sets InSync apart from its competitors? Real customization. The system does not force practices into fixed workflows that don't fit their needs.
During setup, the Qualifacts team tailors dashboards, document templates, clinical alerts, and user roles to reflect how each organization works every day. Because every medical practice field operates differently, you’ll need a system that automatically recognizes this.
The billing system automatically applies ICD codes to appointments and carries those codes through the entire revenue cycle without needing manual re-entry.
E-prescribing includes eMAR and EPCS features for controlled substances. The infrastructure is built on Amazon Web Services, with backup servers in level-one data centers.
Qualifacts claims this setup provides 99% uptime. For practices worn out by systems that force mismatches, InSync offers true operational flexibility.
3. CureMD
CureMD has collected industry awards over the years.
KLAS ranked them number one for Practice Management and EHR in the 1-10 physician category. That recognition reflects a platform genuinely designed around ambulatory workflows rather than hospital systems awkwardly scaled down for smaller practices.
Telehealth functionality stands out. Where other platforms struggle with clunky virtual visit integrations, CureMD scored 85 in an independent telehealth analysis, outperforming both EpicCare and AdvancedMD by significant margins.
Their system lets patients complete intake forms, sign consents, and submit payments online before appointments ever begin.
The AI-powered medical scribe assists with clinical documentation, learning provider preferences over time. Customizable templates adapt to individual charting styles.
Real-time eligibility verification catches insurance problems before they become billing nightmares downstream.
CureMD also maintains ISO certifications for both quality operations and information security, external validation that not every competitor bothers to pursue. For practices prioritizing virtual care capabilities, CureMD delivers.
4. Meditab (IMS)
Intelligent Medical Software, IMS, takes the "all-in-one" promise seriously.
Meditab packages EHR, practice management, patient engagement tools, and telemedicine capabilities together without requiring practices to manage multiple vendor relationships. One company, one platform, one support number to call.
Meditab supports over 40 specialty-specific modules. Think about modules like fertility clinics, allergy and immunology practices, community health centers, FQHCs, cosmetic medicine offices, and more.
Each module includes purpose-built templates, workflows, and documentation structures. A reproductive endocrinology practice operates nothing like a pain management clinic, and IMS reflects that operational reality rather than offering generic templates that fit nobody perfectly.
Recently, they have been introducing AI-powered capabilities, predictive no-show analytics based on patient history, ambient documentation that captures encounter details passively, and automated prior authorization routing that sends documents immediately after visit notes get signed.
Black Book Research recognized Meditab with nine category wins in 2025. Dr. Ghassan Safadi of Safadi and Associates reported a 30% increase in patient visit volume after implementing IMS.
So if you’re on the lookout for AI adoption into your processes, Meditab could be the right fit.
5. Veradigm
Formerly known as Allscripts, Veradigm has been around long enough to accumulate both loyal customers and legitimate legacy frustrations.
The corporate rebrand accompanied renewed strategic focus on ambulatory care excellence and value-based medicine support.
Workflow intelligence drives the platform.
One-click templates populate documentation based on previous encounters, the system learns provider ordering patterns, and surfaces relevant items automatically without requiring manual searches.
HCC alerts remind physicians to document chronic conditions accurately for proper risk adjustment. Risk scores appear directly in the EHR interface, supporting population health management without requiring separate analytics platforms that never quite integrate properly.
In early 2025, Veradigm became the first EHR media platform to earn POCMA certification for point-of-care marketing transparency and compliance.
Telehealth integrates directly without the hassle of third-party workarounds. Providers can access Veradigm EHR Mobile to check schedules, respond to inbox messages, and process prescription refills from anywhere.
For multi-location specialty groups that need strong capabilities and a proven market presence, Veradigm competes well.
6. CompuGroup Medical (CGM)
CompuGroup Medical operates on a global scale, ranking among the largest e-health companies worldwide with annual revenue exceeding €1.19 billion.
That organizational scale translates into substantial research and development investment and long-term corporate stability that smaller vendors simply cannot match.
CGM APRIMA is their leading ambulatory EHR solution in the United States. It features CGM AMBI ambient AI, which documents patient visits by passively listening to clinical conversations.
The system creates structured notes, suggests diagnoses, and recommends billing codes, all without needing manual keyboard input from doctors. Providers using CGM save about three minutes per patient compared to other EHR solutions. Over a full clinic day, this time adds up significantly.
The ARIA RCM service won Best in KLAS for Ambulatory RCM Services in both 2024 and 2025. If this shows anything, it’s that they can be considered a consistent provider.
CGM offers deployment options that competitors often do not: cloud-hosted or on-premise installation based on practice preferences and IT capabilities. For FQHCs and community health centers, CGM ENTERPRISE provides workflows designed to meet complex federal reporting requirements.
7. Eclipse EHR Cloud
Chiropractors and PTs get ignored by the big EHR vendors. Epic doesn't care about your adjustment notes.
Cerner wasn't thinking about rehab workflows when they built their templates. So practices in this space either force-fit generic software or find someone who actually gets it.
Their team has been building Eclipse for three decades. Thirty years of chiropractors and physical therapists telling them what works and what doesn't.
Thousands of facilities run on this thing daily. All these things have gone into perfecting their platform for the end-users.
The cloud version keeps things simple. Monthly subscription. No capital outlay. No contracts locking you in for years. Cancel whenever. Train your staff for free. Try that conversation with your current vendor.
Speed is the real story, though.
Rehab clinics see patients every 15-20 minutes, sometimes faster. You can't spend 10 minutes charting a 15-minute visit. Eclipse's macro system gets compliant E&M notes done in under five.
Daily treatment documentation? Thirty seconds once you've set up your templates. Intake forms populate automatically, and your front desk stops retyping the same information four times.
Generic EHRs treat physical medicine like an afterthought. Eclipse treats it like the whole point.
8. TalkEHR
CareCloud's TalkEHR takes voice interaction seriously as a core design philosophy.
Their voice assistant (named Allison) enables providers to navigate the system, chart clinical encounters, and complete documentation entirely without touching a keyboard or mouse.
Google Voice framework powers the underlying speech recognition engine.
You know that provider who charts while walking to the next exam room? Dictating notes between patients, phone tucked against their shoulder? TalkEHR was basically built for that person.
CareCloud designed this platform around voice from day one. Not voice-as-afterthought. Not "we added dictation."
The whole thing works through spoken commands. Their assistant, Allison, handles navigation, charting, and documentation; hands stay free for actual medicine.
9. Athelas
Athelas stands for something genuinely different in the EHR landscape.
Being built from scratch, this next-gen platform differentiates itself from legacy system foundations. Which, for medical practices looking to modernize and be cloud-first, can be a key determinant in the search for an EHR system.
Powered by Commure, Athelas launched Athelas AIR in mid-2025 with artificial intelligence and revenue cycle management capabilities baked into the architectural foundation rather than awkwardly bolted on afterward.
"When EHRs were first built, they simply digitized existing paper workflows without rethinking how to make those workflows better," CEO Tanay Tandon observed. "What we're left with today are systems that are digital, yes, but clunky, inefficient, and time-consuming." Athelas AIR attempts to fundamentally reimagine the entire clinical documentation and practice management experience.
One area where Athelas stands out is its adoption of new AI technology.
This ultimately allows you to become more efficient and spend more time on patients rather than admin.
Ambient AI scribing captures patient encounters automatically without any input from physicians, and AI agents are running tasks in the background. Autonomous coding creates the correct CPT codes, ICD-10 diagnoses, and modifiers directly from clinical documentation.
More than 100 clients were scheduled for onboarding during the initial launch year.
For practices willing to invest in a new market player with innovative technology, Athelas presents itself as the EHR that truly fulfills the long-promised potential of digital transformation.
Completing the Technology Stack
Your EHR handles clinical documentation. Great.
But what about the phone call at 6 P.M. from a worried patient? The text asks about prescription refills? The fax that never made it into the chart?
In the end, your medical practice should be focused on patients. And if there’s one thing that’s absolutely critical to them, its privacy. And that creates real compliance-related concerns and potentially issues.
HIPAA-compliant communication platforms like iPlum bridge this operational gap. Second phone lines with professional business caller ID keep personal numbers private.
Secure texting maintains proper encryption and comprehensive audit trails. Auto-attendant features route incoming calls professionally without requiring dedicated reception staff during all business hours.
The clean separation between personal and professional communication channels protects both regulatory compliance and provider well-being.
Practices combining robust cloud EHR platforms with properly compliant communication tools create complete operational ecosystems.
Protected health information stays secure across every patient touchpoint. Clinical relationships remain accessible when needed. And healthcare providers maintain the professional boundaries necessary for sustainable long-term practice.
How to Decide Which Platform to Pick
Nine platforms. Different strengths. So, how to decide which one to pick?
One of the main determinants is your specialty focus.
Whereas all of these options work great, you’ll need to ask yourself if any of these have a specific edge within your own specialty.
This can be from a feature point of view, expertise and knowledge, or their current customer base. Make sure to research potential vendors extensively for these factors.
The second deterministic factor is your practice size.
Solo practitioners often choose platforms for features like TalkEHR's voice-first simplicity and accessible pricing.
On the other hand, if you operate out of multiple locations (perhaps in multiple states), you likely need to look at Veradigm’s enterprise capabilities. And growing organizations appreciate InSync's designed scalability.
Risk tolerance plays a role, too. Established vendors like CGM and Veradigm offer organizational stability and proven multi-year track records. Athelas promises genuine innovation but requires accepting faith in a newer platform still proving itself.
So, what’s next? We can recommend that you, first of all, request several live demos. Besides that, talk to actual customer references. It’s critical to gain information from both ends.
That means both the EHR vendor and actual users. Find people in your network who work at other medical practices and ask for their experiences.
Take your time. Get references. Run the numbers. Your practice deserves technology that works as hard as you do.
Disclaimer:This article is intended for general informational purposes and may not reflect the most current features or capabilities of the products or companies mentioned. For the most accurate and up-to-date information, please refer to the official sources of each company.
